Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
| dc.contributor.author | Oliveira, Maria Clara Barbosa de | |
| dc.contributor.author | Melo, Paolo Oliveira | |
| dc.contributor.author | Silva, Marcos Henrique Gonçalves da | |
| dc.contributor.author | Silva, Flávio Santos da | |
| dc.contributor.author | Silva, Felipe Andrade Carvalho da | |
| dc.contributor.author | Araujo, Bruno Vinicios Silva de | |
| dc.contributor.author | Oliveira, Moacir Franco de | |
| dc.contributor.author | Correia, Aristides Tadeu | |
| dc.contributor.author | Sakamoto, Sidnei Miyoshi | |
| dc.contributor.author | Valença, Samuel Santos | |
| dc.contributor.author | Lanzetti, Manuella | |
| dc.contributor.author | Schmidt, Martina | |
| dc.contributor.author | Feitosa, Emanuel Kennedy | |
| dc.date.accessioned | 2023-12-28T19:24:57Z | |
| dc.date.available | 2023-12-28T19:24:57Z | |
| dc.date.issued | 2023-06-23 | |
| dc.description.abstract | This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity. | en |
| dc.description.additionalinformation | Artigo derivado do TCC publicado no Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU). Disponível em: https://repositorio.ufersa.edu.br/handle/prefix/9966. | |
| dc.identifier.bibliographicCitation | Barbosa-de-Oliveira, M. C. et al. Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. Antioxidants, v. 12, i. 6, 2023. DOI: 10.3390/antiox12061258. Disponível em: https://doi.org/10.3390/antiox12061258. | |
| dc.identifier.doi | 10.3390/antiox12061258 | |
| dc.identifier.issn | 2076-3921 | |
| dc.identifier.uri | https://repositorio.ufersa.edu.br/handle/prefix/9967 | |
| dc.language.iso | en | |
| dc.publisher.center | Centro de Ciências Biológicas e da Saúde - CCBS | |
| dc.publisher.country | Switzerland | |
| dc.publisher.initials | MDPI | |
| dc.publisher.institution | MDPI | |
| dc.rights | info:eu-repo/semantics/openAccess | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/br/ | |
| dc.subject.cnpq | CIENCIAS DA SAUDE::MEDICINA | |
| dc.subject.keyword | Cigarette | |
| dc.subject.keyword | Macrophages | |
| dc.subject.keyword | Pulmonary inflammation | |
| dc.subject.keyword | Oxidative stress | |
| dc.subject.keyword | Eugenol | |
| dc.title | Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice | |
| dc.type | info:eu-repo/semantics/article | |
| oaire.citation.issue | 6 | |
| oaire.citation.volume | 12 |