Estudo da cinética de liberação de diclofenaco de sódio em membranas de quitosana modificadas por plasma

Abstract

Chitosan is a biopolymer that has aroused great interest in several branches of science because it has several applications, such as biotechnological, biomedical and pharmaceutical. One of its main characteristics is that it is not absorbed by the body, thus benefiting the release of proteins and drugs. The production of membranes from chitosan has helped this process, since they have a diffuser aspect, controlling the passage of substances of different concentrations from one section to another. In order to improve this mechanism, the treatment provided by the plasma in the membrane is being increasingly studied, as it promotes chemical modifications and consequently morphological changes in the membrane. The drug used was sodium diclofenac, as it had good solubility in water. The membranes were prepared from a 2% (w / v) solution diluted in 2% (v / v) acetic acid, subsequently filtered and placed in the oven, then a stretching process was performed. The plasma treatment was performed at low pressure, making use of the oxygen gas. The tests were carried out in a thermostatic bath, with a fixed temperature at 37 ° C, during a period of 180 minutes, a sample was taken every 5 minutes to be analyzed in the spectrophotometer and thus we obtain the respective values of absorbance, which value will aid in the calculation of permeability. By comparing the permeability values of the membranes with and without plasma, a reduction in the permeability of the treated membrane can be observed, caused by the formation of polar groups on its surface, making it more stable in relation to the drug flow.